McCrackenFrank

John E. Conour, Ph.D.

Patent Agent/Law Clerk

John joined McCracken & Frank in 2005 after completing his doctoral studies in molecular and cellular biology at the University of Illinois at Urbana-Champaign, where he previously received his B.S. in molecular and integrative physiology. At the University of Illinois, John was a USDA National Needs Graduate Fellow in functional genomics. John’s research featured cross-disciplinary collaborations with individuals in the fields of human nutrition, chemical engineering, and biophysics. His research centered on regulatory mechanisms governing cell growth, for which John designed electromechanical devices to control intracellular biochemistry, created novel protein tools for intracellular biochemical analyses, and performed combinatory bioinformatic/in vitro studies on proteins governing cell growth.

Publications

V. L. Kolossov, B. Q. Spring, A. Sokolowski, J. E. Conour, R. M. Clegg, P. J. A. Kenis, H. R. Gaskins, "Engineering Redox-Sensitive Linkers For Genetically Encoded Fret-based Biosensors," Exp. Biol. Med. (Maywood). 233(2):238-48 (2008).

R. C. Gunawan, E. R. Choban, J. E. Conour, L. B. Schook, H. R. Gaskins, P. J. A. Kenis, D. E. Leckband, "Micropatterned immobilized protein gradients direct epithelial cell cycle progression," Langmuir  21:3061-3068 (2005). 

J. E. Conour, W. V. Graham, H. R. Gaskins, “A combined in vitro/bioinformatic investigation of redox regulatory mechanisms governing cell cycle progression,” Physiol. Genomics 18:196-205 (2004).

J. E. Conour, D. Ganessunker, K. A. Tappenden, S. M. Donovan, H. R. Gaskins, “Acidomucin goblet cell expansion induced by parenteral nutrition in the small intestine of piglets,” Am. J. Physiol. Gastrointest. Liver Physiol. 283:1185-1196 (2002).

Abstracts/Presentations
S.R. Chowdhury, J.E. Conour, H.R. Gaskins, "Polarized provision of cysteine affects glutathione biosynthesis without impacting gene expression pathways responsive to oxidative stress in intestinal epithelial cells," Annual Meeting, Federation of American Scientists of Experimental, Washington, D.C. April-May 2007.

S. R. Chowdhury, J. E. Conour, G. M. Nava, H. R. Gaskins, “Polarized provision of cysteine affects redox homeostasis in intestinal Caco2-BBE cells,” Annual Meeting, Federation of American Scientists of Experimental Biology, San Francisco, CA, April 2006.

J. E. Conour, H. R. Gaskins, “Real-Time monitoring of the intracellular redox environment using a novel fluorescence resonance energy transfer-based redox biosensor,” Annual Meeting, Federation of American Scientists of Experimental Biology, San Diego, CA, April 2005.

J. E. Conour, R. C. Gunawan, E. R. Choban, L. A. Rund, J. F. Zachary, H. R. Gaskins, P. J. A. Kenis, D. E. Leckband, L. B. Schook, “In vitro simulation of the intestinal epithelial crypt microenvironment using microfluidic platforms,” International Conference on Systems Biology, St. Louis, MO, November 2003.

R. C. Gunawan, E. R. Choban, J. E. Conour, L. A. Rund, J. F. Zachary, H. R. Gaskins, P. J. A. Kenis, D. E Leckband, L. B. Schook, "Modeling the intestinal epithelial crypt microenvironment using microfluidic platforms," Cell and Molecular Biology & Molecular Biophysics Research Symposium, Champaign, IL, October 2003.

J. E. Conour, W. V. Graham, B. Deplancke, H. R. Gaskins, “In silico identification of redox-regulated cell cycle proteins,” Annual Meeting, American Society for Cell Biology, San Francisco, CA, December 2002.

J. E. Conour, D. Genessunker, S. M. Donovan, H. R. Gaskins, "Total parental nutrition induces sulfomucin goblet cell metaplasia in the small intestine of a neonatal piglet model," Annual Meeting, Federation of American Scientists of Experimental Biology, Orlando, FL, April 2001.